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Cancer Research Studies

Categorized cancer research studies and references which together support the biological activities of CAAT

The following are references of studies conducted in different places and times about the effects amino acids and diet have on the progression and vitality of cancer. Copies of any one or all references can be obtained by contacting us.

Angiogenesis

A 1. Oberley L. W., Obealey T. D., Buetner G. R., "Cell Division in Normal and Transformed Cells," Medical Hypotheses, 1981; 7(1): 21-42.

A 2. Hawk B. P., Oser B. L., Summerson W. H., "Proteins, Their Classification and Properties," Practical Physiological Chemistry, New York: McGraw Hill Book Company, 1955; 183.

A 3. Fotsis T., Pepper M., Aldercruetz H., Fleischmann G., Haases T., Montesano R. Genistein, "A Dietary Derived Inhibitor of In-Vitro Angiogenesis," Proc Nat Acad Sci U.S.A., 1993; 90: 269094.

A 4. Folkman J., "What is the Evidence that Tumors are Angiogenesis-Dependant?" Journal of National Cancer Institute, 1990; 82: 4-6.

Chemotherapy

C 1. Caputo A., Silverstrine B. Lonidamine, "A New Approach to Cancer Therapy," Oncology, 1984, 41(supplement 1): 2-6.

C 2. Vukanovic J., Isaacs J. T., "Human Prosthetic Cancer Cells are Sensitive to Programmed (Apoptotic) Death Induced by The Antiangiogenic Agent Linomide," Cancer Research, 1995; 55: 3517-20.

C 3. Pollak M. N. and Schally A. V., "Mechanisms of Antineoplastic Action of Somatostatin Analogs," Proc Soc Exp Biol Med, 1998; 217: 143-152.

Diet

D 1. Holm H., Staedt E., Schlickeiser G., Gunther H. J., Leweling H., "Substrate Balances Across Colonic Carcinomas in Humans," Cancer Research, 1995, 55: 1373-8.

D 2. Kritchevsky D., " Can Reducing Caloric Intake Also Help Reduce Cancer?" Journal of the National Cancer Institute, 1998; 90: 1766.

D 3. Nolop K. B., Rhodes C. G., Grudin L. H., Beaney R. P., Jones T., "Glucose Utilization in Vivo by Human Pulmonary Neoplasms," Cancer, 1987; 60: 2682-9.

D 4. Holm E., Hagmuller E., Schlickeiser G., Gunter H. J., Leweling H., Op. Cit., 1373-80.

D 5. Holroyde C.P., Reichard G.A., "Carbohydrate Metabolism in Cancer Cachexia, "Cancer Treat Rep., 1981, 65 Supplement; 55-9.

D 6. Harper H.A., Rodwell V.W., Mayes P. A., "Metabolism of Carbohydrates", Review of Practical Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 296.

D 7. Harper H.A., Rodwell V.W., Mayes P. A., "Regulation of Carbohydrate and Lipid Metabolism", Review of Practical Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 370-1.

D 8. Harper H.A., Rodwell V.W., Mayes P. A., "Metabolism of Lipids: Role of the Tissues," Review of Practical Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 356-7.

D 9. Rabinobitz, M., "Consequences of Amino Acid Deprivation in Combination Chemo therapy," Journal of the National Cancer Institute, 1995; 87: 142.

D 10. Gadisseux, P., "Melanomas and Glioblastoma Multiformes can be Starved by Withholding the Amino Acid Tyrosine," Journal of Neurosurgery, 1984; 60: 219-232.

D 11. Lawson D. H., "Reduction in Tumor Size When Diet Is Restricted In The Amino Acids Tyrosine and Phenylalanine," American Journal of Nutrition, 1985; 4(1): 73-84.

D 12.Hawk B. P., Oser B. L., Summerson W. H., "Proteins, Their Classification and Properties," Practical Physiological Chemistry, New York: McGraw Hill Book Company, 1955; 183.

D 13. Harper H. A., Rodwell V. W., Mayes P. A., "Epithelial, Connective, & Nerve Tissues," Review of Practical Physiological Chemistry, Los Altos, California; Lange Medical Pub lications, 1979; 660.

D 14. Holm E., Hagmuller E., Staedt U., Schlickeiser G., Gunther H. J., Leweling H., "Substrate Balances Cross Colonic Carcinomas In Humans," Cancer Research, 1995; 55: 137-8.

D 15. Kremzner K., "Cancers Require More of the Amino Acid Methionine than Normal Cells," Fed. Proc. 1966; 25. Also, Eloranta, T. O., Journal of Biochemistry, 1977; 168: 179-185.

D 16. Kritchevsky D., Journal of the National Cancer Institute, 1998; 90: 1766.

D 17.Hawk P. B., Oser B. L., Summerson W. H., "Carbohydrates, fats, and Protein Metabo lism," Practical Physiological Chemistry, New York, McGraw Hill Book Company, Inc. 1955; 1025.

D 18. Hawk P. B., Oser B. L., Summerson W. H., "Urine Physiological Constituents," Practical Physiological Chemistry, New York, McGraw Hill Book Company, Inc. 1955; 804.

DNA Synthesis

DS 1. Hawk P. B., Oser B. L., Summerson W. H., "Nucleic Acids and Nucleic Proteins," Practi cal Physiological Chemistry, New York: McGraw Hill Book Company, Inc., 1955; 208.

DS 2. Harper H. A., Rodwell V. W., Mayes P. A., "Biosynthesis of Amino Acids," Review of Physiological Chemistry, Los Altos, California: Lange Medical Publication, 1979; 384. GLYCOLYSIS

G 1. Ellis E. M., "Quest for New and Better Colon Cancer Treatments Picks Up Steam," Journal of the National Cancer Institute, 1998; 90: 1858.

G 2. Niederhumber J., Brenan M. .F., Menck H., "The National Cancer Data Base Report on Pancreatic Cancer," Cancer, 1995; 76: 1671-7.

G 3. Warburg O., "On the Origin of Cancer Cells," Science, 1956; 123: 309-14.

G 4. Burk D., "Symposium on Respiratory Enzymes," Madison, WI: University of Wisconsin Press, 1942; 235. Also - Kidd J. G., Winzler R. J., Burk D., Cancer Research,1944;4: 547.

Hormones

H 1. Harper H. A., Rodwell V. W., Mayes P. A., "Hormones: Thyroid, Pancreas, Adrenal & Gastrointestinal Tract," Review of Physiological Chemistry, Los Altos, California, Lange Medical Publications, 1979; 544.

Krebs Cycle

KC 1. Harper H. A., Rodwell V. W., Mayes P. A., "The Critic Acid Cycle—The Catabolism of Acetyl-COA," Review of Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 285.

D 9. Harper H. A., Rodwell V. W., Mayes P. A., "Metabolism of Carbohydrates," Review of Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 294.

D 10. Harper H. A., Rodwell V. W., Mayes P. A., "Biologic Oxidation," Review of Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 292.

D 11. Harper H. A., Rodwell V. W., Mayes P. A., "The Critic Acid Cycle," Review of Physiological Chemistry, Los Altos, California: Lange Medical Publications, 1979; 285-7.

Mitochondria

M 1. Dollinger M., Rosenbaum E., Gable G., "Lung: Non-Small Cell Cancer," Everyone’s Guide to Cancer, Kansas City: Andrews McMeel Publishing 1997; 537.

M 2. St Clair D. K., Oberley L. W., "Manganese Superoxide Dismutase Expression in Human Cancer Cells. A Possible Role of RNA Processing," Free Radical Research Communications, 1991; 12-13 Pt 2: 771-8.

M 3. Oberley L. W., Oberley T. D., Buettner G. R., "Cell Differentiation, Aging and Cancer. The Possible Roles of Superoxide and Superoxide Dismutases," Medical Hypotheses, 1980; 6(3): 249-268.

M 4. Oberley L. W., Oberley T. D., Buettner G. R., "Cell Division in Normal and Transformed Cells: The Possible Role of Superoxide and Hydrogen Peroxide," Medical Hypotheses, 1981: 7(1): 21-42.

M 5. Oberley L. W. and Buettner G. R., "Role of Superoxide Dismutase in Camcer: A Review," Cancer Research, 1979; 39: 1141-49.

M 6. Borrello S., De Leo M. E., Galeotti T., "Defective Gene Expression of MnSOD in Cancer Cells," Molecular Aspects of Medicine, 1993; 14(3): 253-8.

M 7. Brinkman K., Hadewuch J. M., Hofstede T., Burer D. M., Smeitink J. A., Koopmans P. P., "Adverse Effects of Reverse Transcriptase Inhibitors: Mitocochondrial Toxicity as Common Pathway," AIDS, 1998; 12: 1735-1744.

M 8. Lewis W., Perrino F. W., "Severe Toxicity of Fialuridine (FIAU)," N. England Journal of Medicine, 1996; 334: 1136-1138.

M 9. Swartz M. N., "Mitochondrial Toxicity: New Adverse Drug Effects," N. England Journal of Medicine, 1995; 333: 1146-1148.

M 10. McKenzie R., Fried M. W., Sallie R., "Hepatic Failure and Nucleoside Analogue for Chronic Hepatitis B," N. England Journal of Medicine, 1995; 333: 1099-1105.

Supplements

S 1. Broder S., Karp J., "Oncology and Hematology," JAMA, 1994; 271: 1694.

S 2. Kaikobad I., Yong X., Zweier J., "Mitogaenic Signaling Mediated by Oxidants in Ras-Trans- formed Fibroblasts," Science, 1997; 275: 14.

S 3. Fotsis T., Pepper M., Aldercruetz H., Fleischmann G., Haases T., Montesano R. Genistein, "A Dietary Derived Inhibitor of In-Vitro Angiogenesis," Proc Nat Acad Sci U.S.A., 1993; 90: 2690-94.

S 4. Folkman J., "What is the Evidence that Tumors are Angiogenesis-Dependant?" Journal of National Cancer Institute, 1990; 82: 4-6.

S 5. Zbigniew W., Hanausek M., Sherman U., Adam A. K., "Antiproliferative Effect of Dietary Glucarate on the Sprague-Dawley Rat Mammary Gland," Cancer Letters, 1990; 49: 51-57.

S 6. Chandrahar D., Wendy J., Heck B., Downie A. A., Sarroya L., Webb T. E., "The Effect of Calcium Glucarate on Glucuronidase Activity and Glucarate Content of Certain Vegetables and Fruits," Biochemical Medicine and Metabolic Biology, 1990; 43: 83-92.

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