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A.P.John

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Volume 3
News for Patients, Caregivers and Physicians
Fall, 2001
Why Controlled Amino Acid Therapy (CAAT)
Is More Than Just A Diet And Nutritional Supplements
CAAT is more than just a diet and nutritional supplements. CAAT is a scientifically designed bio-nutritional protocol designed to: a) inhibit the synthesis of DNA and tumor growth factors in cancer cells by creating an amino acid imbalance within the body, b) prevent angiogenesis (the building of new blood vessels in cancer cells by depriving them of certain amino acid precursors, such as glycine), c) starve cancer cells by depriving them of glucose and increasing the ketones in the blood through a diet low in carbohydrates and d) inhibiting mitosis (cell division of cancer cells by impairing the synthesis of proteins necessary for the formation of the centrioles (cell structures that control cell division).

Through its special amino acid deprivation formula that replaces part of the animal protein in the daily diet, it's low carbohydrate diet supplemented with scientifically supported nutrients and phytochemicals (it is important to know when to take anti-oxidants and when not to take them), CAAT can attack cancer much in the same way as chemotherapeutic drugs but without the serious toxic side effects. This explains why CAAT works alone and so successfully with chemotherapy.

What do DNA, enzymes and hormones all have in common? They all are synthesized from amino acids or are comprised of amino acids. DNA for example, which also contains phosphorus and sugar molecules called deoxyribosenucleic acid, is synthesized primarily from three amino acids - glycine, aspartic acid and glutamic acid. DNA has one function and one function only which is to design the kind of proteins that are synthesized in each of the trillions of cells that comprise the human body. Some of these proteins become the major components of the structure of the cells, whereas, most of the others function either as enzymes or hormones. No cancer cell can grow or reproduce without first synthesizing DNA. Most cancer drugs are designed to either injure DNA or inhibit it's synthesis. Unfortunately, these drugs can also injure normal cells and their toxicity limits their benefits to cancer patients. CAAT on the other hand inhibits the synthesis of DNA and prevents tumor growth without the toxic side effects.

All enzymes are protein in nature and are made up of amino acids. There are 20 amino acids essential to life. The cells can take any combinations of these 20 amino acids to synthesize thousands of enzymes of different sizes and functions. Some enzymes such as glutathione (one of the most potent anti-oxidant compound in living cells), is made up of only three amino acids, cysteine, glycine and glutamic acid. Other Enzymes can contain as many as several hundred amino acid residues in their molecules. Enzymes control all of the chemical reactions of a cell. Cancer cells cannot grow, reproduce or spread to other parts of the body without the actions of enzymes. CAAT can inhibit or increase the activities of enzymes and thereby stop the growth of cancer cells.

All hormones, with the exception of the steroid hormones are also made up of different combinations of amino acids. Hormones exert their effects by either activating or inhibiting DNA and enzymes. Thyroxine, adrenaline, growth hormone and the insulin-like growth factor are examples of hormones made of amino acids. Steroid hormones include; estrogen, progesterone, cortisone and prolactin.

In its ability to inhibit the activities of certain enzymes, CAAT can also prevent angiogenesis (building of new blood vessels), and cut off the energy supply to cancer cells by impairing a process called glycolysis.

CAAT's supplements include nutrients such as limonene, tocotrienols , curcumin and quercertin, olive leaf extract, vitamins D and E., all of which help fight cancer by inhibiting the activities of certain oncogenes and numerous tumor growth factors.

In CAAT we withhold the intake of most anti-oxidants in the early months of treatment because they can protect cancer cells from entering apoptosis (self-destruction or susicide). Anti-oxidants are added to the daily regiment depending upon the different stages of the disease.

There are 20 amino acids essential to life. CAAT controls the intake of each of these amino acids in the daily diet. .For example we may decrease the intake of tyrosine in some cancers but not if a patient has a heart problem because a deficiency of this amino acid could increase the chances in heart patients developing arrhythmia, a potentially fatal condition. In some cancers we reduce

glycine in the diet because cancer cells need this amino acid to synthesize new blood vessels. However, the body can synthesize this amino acid from some of the other amino acids. We must therefore alter the intake of other amino acids to prevent cancer cells from synthesizing glycine.

In some cancers we will increase the intake of the amino acid phenylalanine in the daily diet because it increases the amounts of ketones in the blood. Also, in some cancers we increase the amounts of fats in the diet because they also increase the amount of ketones in the blood. Ketones help inhibit the activity of an enzyme called phosphofructokinase, which cancer cells require for deriving energy from glucose.

In some cancers we add the supplements limonene and tocotrienols because they can inhibit the activity of the Ras gene. This gene is over active in more than 90 percent of all cancers which speeds up the growth and reproduction of cancer cells.

In summary, CAAT is more than just taking amino acids, vitamins and minerals or going on a low or high carbohydrate or fat diet. CAAT is the scientific administration on a daily basis of each of the more than 44 nutrients essential to the growth, reproduction and life of cancer cells. CAAT is designed to starve and kill off cancer cells without harming normal cells. CAAT is designed to work synergistically with conventional medicine or after conventional medicine has failed.

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© 2003 - Cancer Treatment - Prevention - Research - A.P.John Cancer Institute
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