Non-Hodgkins Lymphoma
What is Non-Hodgkins Lymphoma?
Non-Hodgkins lymphomas are
cancers of the lymph system. When lymphatic cells change (mutate) and grow
unregulated by the processes that normally decide cell growth and death, they
can form tumors.
The lymph system is made up of
thin tubes that branch to all parts of the body. Its job is to fight infection
and disease. The lymph system carries lymph, a colorless fluid containing white
blood cells called lymphocytes. Lymphocytes fight germs in the body.
B-lymphocytes (also called B-cells) make antibodies to fight bacteria, and
T-lymphocytes (also called T-cells) kill viruses and foreign cells and trigger
the B-cells to make antibodies.
Groups of bean-shaped organs
called lymph nodes are located throughout the body at different sites in the
lymph system. Lymph nodes are found in clusters in the abdomen, groins, pelvis,
underarms, and neck. Other parts of the lymph system include the spleen, which
makes lymphocytes and filters blood; the thymus, an organ under the breastbone;
and the tonsils, located in the throat
Because lymph tissue is found
in so many parts of the body, non-Hodgkins lymphoma can start almost anywhere
and can spread to almost any organ in the body. Common sites outside lymph nodes
where lymphoma can start include the stomach, bowel and thyroid
gland
There are many different types
of non-Hodgkins lymphoma. The types are generally described by how quickly the
cancer is growing: low-grade, or "indolent," and high-grade or "aggressive"
forms. These diseases are most common in adults, in who the low-grade and
aggressive NHLs are about equally common. High-grade non-Hodgkins lymphomas are
most common in children.
Disease types further describe
the form of the cancer cells and the structure of the cancerous lymphatic tissue
when viewed under the microscope. Follicular lymphoma cells form clusters, also
known as "follicles" while diffuse cells are evenly distributed through
lymphatic tissue. Non-Hodgkins lymphomas also are classified by whether they
affect the B or T cells of the immune system. Most non-Hodgkins lymphomas (90%)
affect the B cells.
The types and subtypes of
non-Hodgkins lymphoma are determined by how the cells look under a microscope.
About 35 different types of non-Hodgkins lymphoma are recognized. It is very
important to identify these different types because they can behave very
differently and treatments for different types of NHL vary according to the
type.
Low
Grade - These types of lymphoma grow very slowly and tend
to be advanced by the time they cause symptoms. Around 85% to 90% of patients
with these conditions have advanced (stage IV, see below) disease when they
first present to an oncologist. They grow slowly, and usually respond well to
several different types of treatment. They are usually not
curable.
Common types of low grade NHL
include:
- Follicular lymphomas, grades 1
& 2
- Small lymphocytic lymphoma
(also known as chronic lymphocytic leukemia, CLL)
- Marginal zone lymphoma
- MALT lymphoma (lymphoma of
mucosa associated lymphoid tissue)
High
Grade - These types of lymphoma grow rapidly, sometimes very
rapidly. These conditions usually require chemotherapy, which is sometimes very
intensive. These conditions are often curable.
Common
types of aggressive NHL include:
- MALT lymphoma
- Diffuse large B-cell lymphoma
- Medistinal large B-cell
lymphoma
- Burkitts lymphoma
- Lymphoblastic
lymphoma
Some
lymphomas cannot be easily classified as low grade or high grade. One example of
this is a condition known as Mantle cell lymphoma, which has features of high
grade and low-grade lymphoma.
There are many different types of lymphoma.
Age, gender, and a weakened immune system can affect the risk of developing
adult non-Hodgkin’s lymphoma.
Risk factors for adult non-Hodgkin’s lymphoma include the following:
Possible signs of adult non-Hodgkin’s lymphoma include fever, sweating,
fatigue, and weight loss.
These and other symptoms may be caused by adult non-Hodgkin’s lymphoma
or by other conditions. A doctor should be consulted if any of the following
problems occur:
Tests that examine the body and lymph system are used to help detect (find)
and diagnose adult non-Hodgkin’s lymphoma.
The following tests and procedures may be used:
Certain factors affect prognosis (chance of recovery) and treatment options.
The prognosis (chance of recovery) and treatment options depend on the
following:
As we well know, there are many kinds of cancer; unfortunately they all come
about because of the out-of-control growth of abnormal cells.
Healthy
Cells vs. Cancer Cells
Healthy cells are like a
cat. They need structure to
determine the size of bones and shape of the body, tail and whiskers. The DNA in
genes and chromosomes determine this. They need energy to play and prowl
and sustain life. This is derived from chemicals in food. Cats need a system to
deliver chemicals (food nutrients like amino acids, carbohydrates, fats,
vitamins and minerals) to all parts of their body. These are the blood
vessels. Growth factors take a kitten into
a lazy old cat, all the while helping it to function
normally.
The body and its cells are
mostly made up of protein. The building blocks of proteins are substances called
amino acids that in the form of enzymes and hormones literally control every
chemical reaction within the cells. When these are modified, different messages
are sent to a complex control system that can alter their function. There are
twenty different kinds of amino acids that are essential to life. Twelve of
these can be synthesized within the body however; eight must be supplied by the
daily diet.
|
Structure |
|
|
Normal
Cells |
Cancer
Cells |
|
DNA in genes and chromosomes go about their business in a normal
way. |
Cancer cells develop a different DNA or gene structure or acquire
abnormal numbers of chromosomes. |
|
Cells divide in an orderly way to produce more cells only when the
body needs them. |
Cells continue to be created without control or order.
If not needed, a mass of tissue is formed which is called a
tumor. |
|
Energy |
|
|
Normal
Cells |
Cancer
Cells |
|
Cells derive 70% of their energy from a system called the “Krebs
Cycle.” |
Cells have a defective “Krebs Cycle” and derive little or no energy
from it. |
|
Cells derive only 20% of their energy from a system called
“Glycolosis.” |
Cancer cells derive almost all their energy from
“Glycolosis.” |
|
Cells derive most of their energy with the use of
oxygen. |
Cells derive most of their energy in the absence of
oxygen. |
|
Blood
Vessels |
|
|
Normal
Cells |
Cancer
Cells |
|
Cells have a built-in blood vessel
system. |
Cells do not have a built-in blood vessel system.
They require more of certain amino acids to
grow. |
|
Growth
Factors |
|
|
Normal
Cells |
Cancer
Cells |
|
While similar to cancer cells, the amount of them is more in
balance to produce a more normal level of
activity. |
These cells have over produced, require more chemicals (food) and
are over active. |
|
Functions |
|
|
Normal
Cells |
Cancer
Cells |
|
The enzymes and hormones go about business in a normal balanced
manner. |
The enzymes and hormones are either over active or under
active. |
|
Tumors are
Different |
|
|
Benign |
Malignant |
|
Benign tumors are not cancerous. They do not invade
nearby tissues nor spread to other parts of the body. They can be
removed and are not a threat to life. |
Malignant tumors are cancerous. They can invade and
damage nearby tissues and organs and they can break away and enter the blood
stream to form new tumors in other parts of the body. The spread of cancer is
called metastasis. |
After adult non-Hodgkin’s lymphoma has been diagnosed, tests are
done to find out if cancer cells have spread within the lymph system or to
other parts of the body.
The process used to find out the type of cancer and if cancer cells
have spread within the lymph system or to other parts of the body is
called staging. The information gathered from the staging process determines
the stage of the disease. It is important to know the stage of the
disease in order to plan treatment. The following tests and procedures may
be used in the staging process:
- Chest x-ray: An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.
- CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.
- PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radionuclide glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells.
- MRI (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body. This procedure is also called nuclear magnetic resonance imaging (NMRI).
- Gallium scan: A procedure to detect areas of the body where cells, such as cancer cells, are dividing rapidly. A very small amount of radioactive material, gallium, is injected into a vein and travels through the bloodstream. The gallium collects in the bones or other tissues (organs) and is detected by a scanner.
- Bone marrow biopsy: The removal of a small piece of bone and bone marrow by inserting a needle into the hipbone or breastbone. A pathologist views both the bone and bone marrow samples under a microscope to look for signs of cancer.
- Lumbar puncture: A procedure used to collect cerebrospinal fluid from the spinal column. This is done by placing a needle into the spinal column. This procedure is also called an LP or spinal tap.
Stage I
Stage I adult non-Hodgkin’s lymphoma is divided into stage I and stage IE (“E” stands for extranodal and means that the cancer is found in an organ or tissue other than the lymph nodes).
- Stage I: Cancer is found in a single lymph node area.
- Stage IE: Cancer is found in an organ or tissue other than the lymph nodes.
Treatment of indolent, stage I and contiguous stage II adult non-Hodgkin’s lymphoma may include the following:
- Radiation therapy directed at the area where cancer is located.
- Radiation therapy directed at the area where cancer is located and nearby lymph nodes.
- Chemotherapy with radiation therapy.
- Chemotherapy alone or watchful waiting for patients who cannot have radiation therapy.
- Radiation therapy directed at part or all of the lymph system.
Treatment of aggressive, stage I and contiguous stage II adult non-Hodgkin’s lymphoma is usually combination chemotherapy (chemotherapy using more than one drug) with radiation therapy. Chemotherapy alone may also be used.
Stage II
Stage II adult non-Hodgkin’s lymphoma is divided into stage II and stage IIE (“E” stands for extranodal and means that the cancer is found in an organ or tissue other than the lymph nodes).
- Stage II: Cancer is found in two or more lymph node areas on the same side of the diaphragm (the thin muscle below the lungs that helps breathing and separates the chest from the abdomen).
- Stage IIE: Cancer is found in an organ or tissue other than the lymph nodes and may have spread to one or more lymph nodes on the same side of the diaphragm.
Stage III adult non-Hodgkin’s lymphoma is divided into stage III, stage IIIE (“E” stands for extranodal and means that the cancer is found in an organ or tissue other than the lymph nodes), stage IIIS (“S” stands for spleen and means that the cancer is found in the spleen), and stage IIIS+E.
- Stage III: Cancer is found in lymph node areas on both sides of the diaphragm.
- Stage IIIE: Cancer is found in lymph node areas on both sides of the diaphragm and in one area of a nearby organ or tissue other than the lymph nodes.
- Stage IIIS: Cancer is found in lymph node areas on both sides of the diaphragm and in the spleen.
- Stage IIIS+E: Cancer is found in lymph node areas on both sides of the diaphragm, in one area of a nearby organ or tissue, and in the spleen.
In stage IV adult non-Hodgkin’s lymphoma, the cancer either:
- is found throughout at least one organ or tissue other than the lymph nodes and may be in lymph nodes near this organ or tissue; or
- has spread throughout one organ or tissue other than the lymph nodes and has spread to lymph nodes far away from that organ.
Indolent or aggressive:
- Indolent lymphomas: These tend to grow and spread slowly and have few symptoms. They are also called low-grade lymphomas.
- Aggressive lymphomas: These grow and spread quickly and have severe symptoms. Lymphoblastic lymphoma, diffuse small noncleaved cell lymphoma and Burkitt lymphoma are 3 types of aggressive adult non-Hodgkin’s lymphoma. Aggressive lymphomas are seen more frequently in patients who are HIV-positive (AIDS-related lymphoma). Aggressive lymphomas are also called intermediate-grade and high-grade lymphomas.
- Contiguous lymphomas: Lymphomas in which the lymph nodes containing cancer are next to each other.
- Noncontiguous lymphomas: Lymphomas in which the lymph nodes containing cancer are not next to each other, but are on the same side of the diaphragm.
Different types of treatment are available for patients with non-Hodgkin’s lymphoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. Before starting treatment, patients may want to think about taking part in a clinical trial. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.
Three types of standard treatment are used:
1. Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. The way the radiation therapy is given depends on the type and stage of the cancer being treated.
2. Chemotherapy
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). To treat certain types of adult non-Hodgkin’s lymphoma that spread to the brain, CNS prophylaxis (chemotherapy given to kill cancer cells in the brain or spinal cord) may be used. The way the chemotherapy is given depends on the type and stage of the cancer being treated.
What are the side effects of treatment?
The methods used to treat lymphomas are very powerful. That is why the treatment
often causes side effects. Fortunately, most side effects are temporary.
The side effects of chemotherapy depend mainly on the drugs given and the
individual response of the patient. Chemotherapy commonly affects rapidly
growing cells, such as blood cells that fight infection and cells that line
the digestive tract. As a result, patients can have side effects such as a
lowered resistance to infection, loss of appetite, nausea and vomiting, and
mouth sores. They can also lose their hair. These side effects usually end
after chemotherapy is finished.
During radiation therapy, patients can notice a number of side effects. They
can become unusually tired as the treatment continues. Resting as much as
possible is important. Skin reactions (redness or dryness) in the area being
treated are common. Patients should be gentle with the treated area of skin.
Lotions and creams should not be used without the doctor's advice. When the
chest and neck area is treated, patients may have a dry, sore throat and can
have some trouble swallowing. Sometimes, they have shortness of breath or
a dry cough. Radiation treatment to the lower abdomen can cause nausea, vomiting,
or diarrhea. Some patients have tingling or numbness in their arms, legs,
and lower back. These side effects gradually disappear when treatment is over.
Loss of appetite can be a problem for patients receiving chemotherapy or radiation
therapy. Researchers are learning that patients who eat well are better able
to tolerate the side effects of their treatment. Therefore, good nutrition
is an important part of the treatment plan. Eating well means getting enough
calories to prevent weight loss and having enough protein in the diet to build
and repair skin, hair, muscles, and organs. Many patients find that eating
several small meals and snacks throughout the day is easier than trying to
have three large meals.
The side effects that patients have during cancer therapy vary from person
to person and may even be different from one treatment to the next. Attempts
are made to plan treatment to keep problems to a minimum. Doctors, nurses,
and dietitians can explain the side effects of cancer treatment and can suggest
ways to deal with them.
What happens after treatment for non-Hodgkin's lymphoma?
Regular follow-up exams are very important for anyone who has been treated
for non-Hodgkin's lymphoma. Most relapses occur in the first 2 years after
therapy.
Generally, checkups include a careful physical exam, x-rays, blood tests,
and other laboratory tests. Patients should follow their doctor's recommendations
on health care and checkups. Having regular checkups allows problems to be
detected and treated promptly should they arise.
When people have cancer, life can change for them and for the people who care
about them. These changes in daily life can be difficult to handle. It is
natural for a person with non-Hodgkin's lymphoma to have many different and
sometimes confusing emotions.
At times, patients and family members may be depressed, angry, or frightened.
At other times, feelings may vary from hope to despair or from courage to
fear. Patients usually are better able to cope with their emotions if they
can talk openly about their illness and their feelings with family members
and friends.
Concerns about the future, as well as about medical tests, treatments, a hospital
stay, and medical bills, are common. Talking to doctors, nurses, or other
members of the health care team may help to ease fear and confusion. Patients
can take an active part in decisions about their medical care by asking questions
about their treatment. Patients and family members often find it helpful to
write down questions for the doctor as they think of them. Taking notes during
visits to the doctor can help them remember what was said. They should ask
the doctor to explain anything that is not clear.
Patients have many important questions to ask about their disease, and their
doctor is the best person to provide answers. Most people want to learn what
type of lymphoma they have, how the disease can be treated, and how successful
the treatment is likely to be.
INTEGRATIVE THERAPY
THE SCIENTIFICALLY FORMULATED AMINO ACID THERAPY
(Keep in mind, CAAT is much more than just a “diet”; it is an amino acid, carbohydrate, & glucose REDUCTION protocol which strategically uses the chemical reactions of amino acids, foods, and nutritional supplements to impair the development of cancer cells, thus starving them to death.) Clinical trials have already been done with humans using amino acid depravation formulas, and with much success. (Journal American Medical Association. 1967; 200:211)
CAAT is a course of therapy to control a patient’s amino acid intake. This is achieved by taking certain foods out of a persons’ daily food plan for a short time and by replacing them with a scientifically supported formula of amino acids. It is also important to emphasize that the food plan that accompanies the amino acid formula needs to be followed so not to offset any of the benefits we are creating by depriving the cancer cells the nutrients they need to grow. Also, it is important to realize that the patient does not need to abandon their conventional cancer treatment, (surgery, chemotherapy, radiation, hormone treatments) nor is it recommended that they do so unless it has already failed them. CAAT works synergistically with chemotherapy and/or radiation to enhance their benefits (see study by Dr. Marco Rabinowitz of the National Cancer Institute). His report on amino acid deprivation, such as with Controlled Amino Acid Therapy (CAAT), proven to inhibit phosphofructokinase which shuts down the energy supply to cancer cells, simultaneously enhancing the benefits of chemotherapy while lessening their toxic side effects. CAAT has also proven to work successfully alone.
Phase 1: CAAT Formulation
The most important component of CAAT is the scientifically formulated amino acids. Based on the specific formula for each cancer, it consists of separate amino acids, citric acid, and small amounts of sodium benzoate. Each formula replaces most of the regular daily proteins found in meats, dairy, fish, beans and nuts, which cancer cells can derive their energy from. The CAAT formula taken two times per day will nourish the healthy cells while causing the cancer cells to starve to death. Of course each individual has specific needs concerning their diet, and this is explained in the second phase of the protocol as well as with a specialist at the Institute when beginning the CAAT therapy.
Phase 2: Daily Food Intake
DISCLAIMER: The following food program SHOULD NOT be consumed without the amino acid formula and without consent from your doctor and our Institute.
Breakfast:
*1/2 Grapefruit or 1-orange or 6-ounces of fresh orange juice.
Whey Enhanced Protein (Vanilla Flavor – Vitamin Shoppe Brand) approximately
10 – 12 grams of protein – read label carefully, based on 150
lb. person ].
A serving of Grits (Butter, cinnamon and other spices are okay).
1 cup of green or black tea (Fructose is sweetener of choice).
* Do Not have ½ grapefruit if taking Chemotherapy
Explanation: ½ Grapefruit or 1 orange or 6 ounces of fresh orange juice are rich in the natural nutrients called Limonene and Citric Acid. Limonene helps shut down the Ras cancer gene which is over active in 90 percent of all cancers. Citric Acid helps shut down glycolosis which in turn helps starve cancer cells to death.
Whey Enhanced Protein (Vanilla Flavor – Vitamin Shoppe Brand) Phosphorus
is a nutrient that cancer cells must utilize in order to grow and reproduce.
This brand of whey protein is very low in phosphorous and contains no additional
vitamins, so when using approximately 10 – 12 grams of protein per
150 lb. person, it helps to protect normal cells, maintain a normal appetite,
and also helps to fight edema. (Edema is the swelling or water build up
in the legs or other sites in the body)
Whey protein is included in the daily menu of all advanced or metastatic
cancer patients. When treating cancers that are stable or have regressed
in size, patients then have the option of including other protein foods
at their breakfast meals such as cottage cheese, yogurt, or soy foods. Eggs
are allowed in the diets of patients with lymphoma and brain cancers.
Grits or Cream of Wheat or 1 slice of white toast or ½
plain bagel or ½ English muffin (Butter is okay)
Grits or white rice is the preferred carbohydrate food at each meal. The
other choices are options once the patient’s cancer is stable or reduced
in size. Unrefined carbohydrates are included in the CAAT menu instead of
whole grains to deprive cancer cells of a certain B-complex vitamin called
Pyridoxine (Vitamin B-6). Cancer cells require this vitamin to manufacture
certain amino acids that we keep away from through CAAT’s amino acid
reduction formula and diet.
Grits is the preferred carbohydrate food at all meals instead of rice, corn,
or pasta because it helps deplete Tryptophan in the body, which is essential
for the growth and spreading of cancer cells.
1 cup of green or black tea, using fructose as the sweetener of choice.
These teas are rich sources of several compounds that help shut down glycolosis
and cut off the energy supply to cancer cells. Also, green or regular tea
helps to prevent certain hormones and tumor growth factors from stimulating
cancer cells to grow and metastasize to other parts of the body. Brassica
teas can also be taken because they contain sulphorane, a nutrient that
inhibits cancer growth, and also shuts down the cancer genes.
* Why we use fructose as the sweetener of choice will be explained in detail
at the end of this phase of the CAAT protocol.
Lunch:
Amino acid formula (4 level plastic scoops) mixed with any of the
following: Water & Fructose; Sugar free Kool-Aid; Diet ginger ale; Fresh
lemonade & Fructose; Chicken or Beef broth; V8 juice.
Generous amounts of One cooked vegetable or a combination of the
following: asparagus, broccoli, cabbage, brussell sprouts, spinach, squash,
string beans.
One serving (1/2 cup)of fresh fruit. Choice of: pear, orange, blueberries,
raspberries, strawberries.
1 serving (moderate) of grits or corn or rice or pasta
(Add tomato sauce or butter)
1 tablespoon of coconut oil
8 to 10 black or green olives
2 tablespoons of vinegar (minimum of 5% acidity) add to vegetables or food
1 cup of green or black tea (Fructose as desired)
Explanation:
This Amino Acid Reduction Formula (4 level plastic scoops may vary) combined with the special diet, allows the CAAT Protocol to reduce certain amino acids in the daily diet of the cancer patient, and is designed to replace most of the animal protein in the diet. Cancer cells require the amino acids glycine, serine, glutamic acid, and aspartic acid to synthesize DNA, build new blood vessels or duplicate its entire contents of proteins. Also, cancer cells require these and certain other amino acids in order to synthesize other proteins that act as growth promoting hormones or tumor growth factors. CAAT impairs the synthesis of a protein called elastin, which is absolutely essential to the manufacture of new blood vessels. The Amino Acid Reduction Formula, diet, certain phytochemicals and herbs work efficaciously to attack cancer cells at each and every biological front.
The generous amounts of one cooked vegetable or a combination of such helps keep normal cells healthy. They are low in carbohydrates and proteins, and high in phytochemicals, compounds which help fight cancer. Patients are allowed to eat these vegetables and salads whenever desired.
The 8 to 10 olives are rich in squalene and oleic acid, nutrients that have been reported to inhibit certain cancer growth factors. The calories in olives also help control body weight and increases ketones in the blood. Ketones help fight cancer by impairing glycolosis – a process in which cancer cells depend almost exclusively upon for their daily supply of energy. Vinegar (and fructose) are two natural products that increase the production of both ACETIC ACID and CITRIC ACID in the body.
Acetic acid and citric acid also help fight cancer by shutting down the
process of glycolosis.
Normal cells derive most of their daily energy supply from acetic acid and
citric acid, where as cancer cells derive most of their daily energy from
glycolosis.
Dinner:
Amino acid formula (4 plastic level scoops) mixed with any of the
following: Water & fructose; Sugar free Kool–Ade; Diet Ginger
Ale; Fresh lemonade & Fructose; Chicken or Beef broth; V8 Juice.
Generous amounts of One cooked vegetable or a combination of the following:
asparagus, broccoli, cabbage, brussel sprouts, spinach, squash, string beans.
One serving (1/2 cup) of stewed plums with fresh cream & fructose; use
4-ounces of orange juice if plums are not in season.
Avacado salad with lettuce, tomatoes, celery, onions, with lemon juice and
coconut oil or olive oil.
2 tablespoons of vinegar (minimum of 5% acidity) add to vegetables or food.
1 serving of grits or corn or pasta or rice (Add garlic
and butter or tomato sauce)
1 cup of green or black tea (Fructose as desired)
Mid Evening Snack: Ketogenic Cocktail – 2 ounces of fresh
cream, ½ ounce each of both coconut & olive oil, 1 tablespoon
of Fructose.
Sugar free Jell-O with whipped cream & Fructose or 1 plum or 4 ounces
of orange juice.
Explanation: The sugar free jell-o helps to appease the appetite. Plums contain quinlic acid, which is converted into benzoic acid in the body and which in turn helps to deplete the availability of the amino acid Glycine (Glycine is essential to the synthesis of DNA for cancer cells) and the proteins that cancer cells require to build new blood vessels and their tumor growth factors. If underweight take two ounces of light cream and one ounce of olive oil/coconut oil as needed to maintain weight.
Optional Meal:
3 to 4 ounces of Veal, Fish of choice, Beef, Chicken breast, and 1-slice of white bread.
Consume this meal with a minimum of 3 hours before or after taking the amino acids.
Explanation: If the patient is 10 or more pounds underweight or if their albumin levels are below normal is when the optional meal is allowed. This meal should be eaten a minimum of 3 hours before or after taking the amino acids. CAAT provides sufficient protein to maintain the health of normal cells and adequate amounts of calories to maintain desired body weight. Any proteins taken in excess of amounts recommended in the diet will counter act the benefits of the CAAT protocol.
Special Diets: A special diet will be created for any cancer patient whose ability to consume food and liquids has placed them in a critical situation. When a patient is using a feeding apparatus, or they have become too weak or lethargic to eat and drink the daily minimum amount for survival, we will break up the total breakfast, lunch, and dinner over a period of every 2 hours during the entire day until the patient is capable of returning to a daily diet as outlined above.
Carbohydrate and glucose reduction in this diet: CAAT’S dietary menu provides approximately 20 percent of its calories in the form of carbohydrates. Calories need not be a focal point or counted daily. It is recommended that all patients combat their cancers by keeping their body weight at normal or slightly below normal levels. A patient’s desired body weight is regulated by their rate of metabolism, which in turn is regulated by their blood levels of thyroxine, cortisone, insulin, and the amounts of fats and oils in the diet. Studies with human cancer patients and laboratory animals show that reducing the calories of carbohydrates (glucose) in their daily diet by only 10 percent reduced the size of cancerous tumors. When carbohydrate (glucose) calories were reduced 40 percent, the cancers disappeared. It is recommended that those patients who are obese gradually and systematically lose their excess weight to increase the efficiency of the CAAT protocol. Those patients who are underweight shoudn’t gain weight unless they are more than 10 pounds below normal levels. When a patient is underweight due to anorexia or cachexia, such illnesses must be addressed before the CAAT protocol can begin.
Why we use Fructose and Vinegar to treat cancer:
Nobel Prize winner Dr. Otto Warburg discovered more than 50 years ago that all cancer cells produce inordinate amount of lactic acid but he couldn’t explain why.
In 2001 our Institute published the first study to show that cancer cells produce excess amounts of lactic acid because they could not access the oxygen in compartments in the cells called the mitochondria. This provided evidence that cancer cells depend almost exclusively upon glycolosis or the metabolism of glucose as their major source of energy.
Dr. Spitz and Dr. Lee with other cancer researchers published studies showing that when cancer cells are deprived glucose, their energy supply is cut off which causes these cancer cells to commit suicide.
Therefore shutting down glycolosis would be one means of destroying cancer cells because energy can only be derived from glucose through the metabolic process called glycolosis.
Recently our Cancer Institute discovered that both acetic acid and citric acid could inhibit the activity of a key enzyme in glycolosis called phosphofructokinase, which in turn shuts down the process of glycolosis. Our cancer Institute is the first to introduce both fructose and vinegar as treatments for cancer because they either contain or produce acetic acid.
In conclusion, fructose and vinegar are added as supplements to the CAAT protocol because of their acetic acid properties that help shut down glycolosis, shutting off cancer cells energy supply and causing them to die off.
Phase 3: Nutritional Supplements
Nutritional supplements are based on each unique situation. For example, slow-growing cancers produce low levels of toxic free radicals. Tumor cells that grow aggressively produce large amounts of toxic free radicals. The patient will be instructed whether or not to take anti-oxidants (in a nutritional supplement), and at what dosage, according to the levels of toxic free radicals produced in the cancerous cells.
An example of how nutritional supplements can help manipulate cancer cells involves vitamin B-6 (pyroxidine) There are four amino acids essential to the synthesis of DNA. However, those amino acids cannot be synthesized without a certain enzyme, which includes vitamin B-6 among other components. Any supplement containing vitamin B-6 SHOULD NOT be taken during the first 2 months of the CAAT protocol.
The patient will be instructed as to which nutritional supplements or phytochemicals should be purchased and at what dosage strength. Keep in mind that each supplement only complements the CAAT protocol. However, when they are combined they augment the therapeutic benefits of the aminoacid, carbohydrate, and glucose reduction diet.
Parsley: Contains ingredients that can help shut down certain enzymes called Epithelial Growth Factors, which stimulate the growth and spread of cancer. ( CAAT’S amino acid reduction diet works in the same manner )
Vitamin D: Helps activate in many kinds of cancers enzymes called Phosphotases, which literally shut down the activities of other enzymes called Kinases, which are essential to the growth and reproduction of cancer cells.
Green Tea Extract: Phytochemicals in tea help shut down glycolosis (cancer cell’s main supplier of energy) and thereby help to starve cancer cells to death. These effects help complement the effects of CAAT’S carbohydrate reduction.
Anti-Oxidants: The controversy as to whether or not to treat cancer with anti-oxidants is slowly resolving with the current understanding of how they affect the activity of genes and enzymes in cancer cells. The prevailing data shows that the benefits or lack of benefits depend upon the oxidative state the cancer cells are in. Anti-oxidants taken when the cells are in a very high oxidative state may prevent cancer cells from entering apoptosis ( apoptosis is when a cancer cell commits suicide) When oxidative stress in cancer cells is only slightly above normal, anti-oxidants are then expected to stop their growth and reproduction.
Blood Chemistry: Blood tests are usually taken every 6 to 8 weeks, depending upon the results of each test. Not only is it important to monitor the tumor markers but equally important to keep abreast of the overall health of normal tissues and organs. For example, it is important to learn of the health of the kidneys and liver, whether the body is producing sufficient red and white blood cells, etc. Low albumin levels most often indicate insufficient intake of proteins in the diet and this problem would have to be addressed. CAAT is designed to attack cancer but keep the normal cells and tissues functioning harmoniously.
Whey Protein: This protein food is recommended at the breakfast meal to help meet the daily needs of amino acids for the normal cells of the body, and to help keep albumin levels normal and to help prevent edema. We recommend Whey protein purchased from the Vitamin Shoppe because it is the only brand that we have seen with no phosphorous or additional vitamins added to it.
Grits: Grits are also recommended at the breakfast meal in place of whole grains because it is low in vitamin B-6. Cancer cells require B-6 to manufacture the amino acid Glycine, which is required for DNA synthesis. Grits, instead of whole grains, therefore helps prevent cancer cells from manufacturing DNA and building new blood vessels.
Calcium D-Glucurate: This phytochemical helps the body to retain a compound called Glucuronic acid. This is necessary to eliminate both estrogen and testosterone from the body. This is why Calcium D-Glucurate is added to the regiments of patients with breast & prostate cancers. Calcium D-Glucurate is not to be confused with calcium carbonate, which is nothing more than a calcium supplement.
D-Limonene: This phytochemical found mostly in citrus fruits blocks the process called Isoprenylation, which is necessary for tumor growth factors such as the RAS gene, Epithelial Growth factor, Tyrosine Kinase, and Insulin-Like-Growth-factor, to send their signals into the nucleus of a cancer cell and directs them to grow and divide into more cancer cells.
Tocotrienols: This member of the Vitamin E family also helps shut down Isoprenylation and assists D-Limonene in blocking the actions of the various tumor growth factors. More specifically, tocotrienols shut down an enzyme called HMG-2, which is essential to the synthesis of the building blocks that form the Isoprenylation process.
Niacin: This B-Complex vitamin works with D-limonene and the Tocotrienols to shut down the process of Isoprenylation, which as mentioned above prevents the cancer promoting RAS genes from sending signals into the nucleus of the cell. Niacin also helps deplete thee amino acid Glycine, which cancer cells need to synthesize DNA. And by reducing cholesterole in the body, Niacin helps lower the production of estrogen and testosterone.
Choline: This B-complex vitamin is included in our supplement list to help the liver metabolize Niacin and other compounds and to help fight fatigue that accompanies most forms of cancer.
Selenium: Numerous studies show that this mineral can interfere with the activity of certain genes that promote the growth of cancer and to induce cancer cells to commit suicide (apoptosis)
Perilla Oil: This oil is rich in Alpha Linolenic Acid which can inhibit the growth of cancer cells in several ways. One way is to inhibit the synthesis in the body of a tumor growth promotin hormone called Prostaglandin-2, also, Alpha Linolenic Acid inhibits the actions of certain genes that promote the growth of cancer cells. Linolenic acid is not to be confused with linoleic acid, which is a bad fat that stimulates the growth of cancer cells. This bad fat, linoleic acid, is found in all vegetable oils and nuts (With the exception of coconut oil). Olive oil has the least amount of this bad fat.
Super Miraforte: This herb impairs the synthesis of estrogen from
testosterone in the body and is included in the regiments of women with
breast cancer.
Licorice Root Extract & Pantothenic Acid: This herb and vitamin are
added to the regiment when it is desirable to produce steroid like actions
in the body. Also used to help patient’s gain weight and to inhibit
the growth of lymphomas and leukemia’s.
Resveratrol: This phytochemical blocks the actions of a number of a number of cancer promoting genes thereby causing cancer cells to enter into apoptosis (cell death) and is included in the treatment of all cancers.
Indole-3 Carbinol & D.I.M.: These two phytochemicals block the actions of both estrogen and testosterone and are included in the regiments of both breast and prostate gland cancer.
Melatonin: Numerous studies show that this hormone blocks the synthesis of the cancer promoting chemicals in the body called Leukotrienes, and is included in the treatment of all cancers.
Artho Pro System: This combination of herbs and phytochemicals inhibits the synthesis of the cancer promoting hormone called Prostaglandin-2 and the Leukotriens and replaces the drug celebrex when liver problems are present. The Prostaglandin hormone is over active in most cancers and stimulates cancer growth. The body manufactures the Prostaglandin hormone from the bad fat, Linoleic acid, mentioned above.
Licorice Root Extract & Pantothenic Acid: This HERB and
VITAMIN are added to the regiment when it is desirable to produce
steroid like actions in the body. Used also to help patients gain weight
and ti inhibit the growth of Lymphomas and Leukemias.
CAAT is designed to attack cancer, while keeping normal cells and tissues functioning harmoniously.
* When considering any type of complementary cancer treatment or alternative cancer treatment, always consult with your physician first, as possible interactions could reduce your regimen’s efficacy.
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